个人简介：

徐登球，副研究员、硕士研究生导师，安徽省“优青”。2014年至2020年在中国药科大学获得博士学位，随后在南京大学从事博士后科研工作，2022年底加入安徽医科大学第一附属医院，担任专职科研PI。长期聚焦于肝脏线粒体代谢健康的关键科学问题，取得系统性重要成果。在J Exp Med.、J Cachexia Sarcopenia Muscle.、Sci Transl Med.、J Clin Invest.、Nat Commun.、Pharmacol Sin.、Oncogene.、Br J Pharmacol.等主流学术期刊发表研究论文近20篇，并申请发明专利2项，PCT 1项。

研究方向：

新药筛选和肝脏与骨骼肌线粒体代谢控制

联系方式：

邮箱： xudengqiu@nju.edu.cn

主持课题：

国家自然科学基金青年项目（32100942）                                  

安徽省优秀青年基金（2408085Y041）

第15批中国博士后科学基金特别资助（270485）

安徽省教育厅重点项目（2024AH050824）

第69批中国博士后科学基金面上资助（003019）

安徽医科大学第一附属医院人才启动项目（1653）

江苏省资助招收博士后研究项目（2021Z030）

江苏省博士后科研资助资助项目（2021K584C）

新疆维吾尔自治区重点研发项目（ 2022TSYCLJ009 ）

代表性论文：

(1) Yujing Yin^#; Dengqiu Xu^# ( 共同第一作者 ); Yan Mao^#; Liwei Xiao; Zongchao Sun; Jing Liu; Danxia Zhou; Zhisheng Xu; Lin Liu; Tingting Fu; Chenyun Ding; Qiqi Guo; Wanping Sun; Zheng Zhou; Likun Yang; Yuhuan Jia; Xinyi Chen; Zhenji Gan*; FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics, Journal of Experimental Medicine, 2022, 219(5): 1491-1511.

(2) Dengqiu Xu; Sijia Li; Lu Wang; Jingwei Jiang; Lei Zhao; Xiaofei Huang; Zeren Sun; Chunjie Li; Lixin Sun; Xihua Li*; Zhenzhou Jiang*; Luyong Zhang*; TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy, Journal of Cachexia, Sarcopenia and Muscle, 2021, 12(1): 192-208.

(3) Dengqiu Xu; Lei Zhao; Jingwei Jiang; Sijia Li; Zeren Sun; Xiaofei Huang; Chunjie Li; Tao Wang; Lixin Sun; Xihua Li*; Zhenzhou Jiang*; Luyong Zhang*; A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1, Journal of Cachexia, Sarcopenia and Muscle, 2020, 11(5): 1306-1320.

(4) Dengqiu Xu^# (共同第一作者); Zhao L^#, Li S; Huang X; Li C, Sun L; Li X; Zhang L*; Jiang Z*. Catalpol counteracts the pathology in a mouse model of Duchenne muscular dystrophy by inhibiting the TGF-β1/TAK1 signaling pathway. Acta Pharmacol Sin. 2021 Jul; 42(7): 1080-1089.

(5) Dengqiu Xu; Li C; Jiang Z; Wang L; Huang H; Li Z; Sun L; Fan S; Zhang L*; Wang T*. The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis. Acta Pharmacol Sin. 2020 Jun; 41 (6): 791-799.

(6) Longpo Geng^#; Mingming Zhu^#; Dongjun Luo^#; Huihui Chen^#; Binghua Li; Yuanxiang Lao; Hongda An; Yue Wu; Yunzheng Li; Anliang Xia; Yi Shi; Zhuting Tong; Shanshan Lu; Xu D*(共同通讯作者); Xu Wang*; Wenjun Zhang*; Beicheng Sun*; Zhu Xu*; TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma, Oncogene, 2024, 23(4): 2935-2943.

(7) Mao Y, Jin Z, Yang J, Xu D, Zhao L, Kiram A, Yin Y, Zhou D, Sun Z, Xiao L, Zhou Z, Yang L, Fu T, Xu Z, Jia Y, Chen X, Niu FN, Li X, Zhu Z, Gan Z. Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouse. Sci Transl Med. 2024 Jun 5;16(750): eadk9811.

(8) Sun Z, Yang L, Kiram A, Yang J, Yang Z, Xiao L, Yin Y, Liu J, Mao Y, Zhou D, Yu H, Zhou Z, Xu D, Jia Y, Ding C, Guo Q, Wang H, Li Y, Wang L, Fu T, Hu S, Gan Z. FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment. Nat Commun. 2023 Nov 6;14(1):7136.

(9) Yin Y, Xu D, Mao Y, Gan Z*. Comments on FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. J Mol Cell Biol. 2022 May 18.

(10) Zeren Sun^#; Dengqiu Xu^# ( 共同第一作者 ); Lei Zhao; Xihua Li; Sijia Li; Xiaofei Huang; Chunjie Li; Lixin Sun; Bin Liu; Zhenzhou Jiang; Luyong Zhang; A new therapeutic effect of fenofibrate in Duchenne muscular dystrophy: The promotion of myostatin degradation, British Journal of Pharmacology, 2021, 179(6): 1237-1250.

(11) He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z, Liu Y. IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay. J Clin Invest. 2021 Jul 20;131(17): e143737.

(12) Xu D, Huang X, Hassan HM, Wang L, Li S, Jiang Z, Zhang L*, Wang T*. Hypoglycemic effect of catalpol in a mouse model of high-fat diet induced prediabetes. Appl Physiol Nutr Metab. 2020 Oct; 45(10): 1127-1137.

(13) Xu D#, Jiang Z#, Sun Z, Wang L, Zhao G, Hassan HM, Fan S, Zhou W, Han S, Zhang L*, Wang T*. Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high-fat-diet-induced pre-diabetes. J Cel lPhysiol. 2019 May; 234 (5): 7510-7523.

(14) Xu D, Wang L, Jiang Z, Zhao G, Hassan HM, Sun L, Fan S, Zhou Z, Zhang L*, Wang T*. A new hypoglycemic mechanism of catalpol revealed by enhancing MyoD/MyoG-mediated myogenesis. Life Sci. 2018 Sep 15; 209:313-323.