个人简介：
王守宇，博士，安徽医科大学第一附属医院教授，博士生导师。课题组围绕肿瘤表观遗传的分子机制及临床转化展开研究，以第一或通讯作者在 Nature Cell Biology，Nature Cancer，Gut (3篇)，Advanced Science，The Journal of Clinical Investigation，Cell Research，Clinical Cancer Research，Nucleic Acids Research，Cancer Letters等杂志发表论文40余篇；ESI高被引论文2篇；主持国家自然科学基金5项和江苏省杰出青年科学基金等。曾获教育部高等学校自然科学奖二等奖，江苏省科学技术奖，华夏医学奖和国际毒理学会青年学者奖。
研究方向：
肿瘤表观遗传
联系方式：
shouyuwang@ahmu.edu.cn
主持课题：
(1) 国家自然科学基金面上项目（No. 82273157），RBM15蛋白液-液相分离激活NRF2信号通路促进胃癌转移的分子机制，2023/01-2026/12
(2) 国家自然科学基金面上项目（No. 82073114），RNA乙酰转移酶NAT10通过HK2调控糖酵解促进胃癌生长和转移的作用机制研究，2021/01-2024/12
(3) 国家自然科学基金面上项目（No. 81773383），长链非编码RNA通过JAK2调控环境因素诱导胃上皮细胞恶性转化的作用机制，2018/01-2021/12
(4) 国家自然科学基金面上项目（No. 81370078），miR-28-TXNL1-XRCC1 轴在顺铂诱导胃癌细胞凋亡中的作用及分子机制，2014/01-2017/12
(5) 国家自然科学基金青年项目（No. 81001231），XRCC1 在DNA 损伤修复和细胞凋亡中的作用及其分子机制，2011/01-2013/12
(6) 江苏省杰出青年基金（No. BK20170047），环境致癌物诱导胃癌发生的作用机制及干预研究，2017/06-2020/12
代表性论文：
（#第一作者，*通讯作者）
(1) Zhangding Wang#, Qiang Wang#, Chen Chen#, Xiaoya Zhao#, Honggang Wang#,Lei Xu, Yao Fu, Guang Huang, Mengmeng Li, Jiawen Xu, Qianyi Zhang, Bo Wang, Guifang Xu*, Lei Wang*, Xiaoping Zou*, Shouyu Wang*. NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma. Gut. 2023 Mar 28; gutjnl-2022-328408.
(2) Anliang Xia#, Qi Yue#, Mingming Zhu#, Jianbo Xu#, Siyuan Liu, Yue Wu, Zhangding Wang, Zhu Xu, Hongda An, Qiang Wang*, Shouyu Wang*, Beicheng Sun*. The cancer-testis lncRNA LINC01977 promotes HCC progression by interacting with RBM39 to prevent Notch2 ubiquitination. Cell Death Discov. 2023 May 18;9(1):169.
(3) Qiang Wang#, Chen Chen#, Xiao Xu#, Chuanjun Shu#, Changchang Cao#, Zhangding Wang, Yao Fu, Lei Xu, Kaiyue Xu, Jiawen Xu, Anliang Xia, Bo Wang, Guifang Xu, Xiaoping Zou, Ruibao Su, Wei Kang, Yuanchao Xue*, Ran Mo*, Beicheng Sun*, Shouyu Wang*. APAF1-binding Long Noncoding RNA promotes tumor growth and multidrug resistance in gastric cancer by blocking apoptosome assembly. Advanced Science. 2022 Aug 17; e2201889.
(4) Anliang Xia#, Wenwen Yuan#, Qiang Wang#, Jianbo Xu#, Yayun Gu, Liansheng Zhang, Chen Chen, Zhangding Wang, Di Wu, Qifeng He, Weiwei Yu, Fei Wang, Cailin Xue, Yan Zhang, Guojian Bao, Xuewen Tao, Siyuan Liu, Shouyu Wang*, Zhibin Hu*, Beicheng Sun*. The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription. Nature Cancer. 2022 Feb;3(2):203-218.
(5) Zhangding Wang#, Yao Fu#, Anliang Xia#, Chen Chen, Jiamu Qu, Guifang Xu, Xiaoping Zou*, Qiang Wang*, Shouyu Wang*. Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma. Cell Proliferation. 2021 Oct;54(10): e13117.
(6) Chen Chen#, Ningmei Shen#, Yali Chen, Pinping Jiang, Wei Sun, Qiang Wang, Zhangding Wang, Yi Jiang, Wenjun Cheng*, Shilong Fu*, Shouyu Wang*. LncCCLM inhibits lymphatic metastasis of cervical cancer by promoting STAU1-mediated IGF-1 mRNA degradation. Cancer Letters. 2021 July; 518:169–179.
(7) Qiang Wang#, Chen Chen#, Qingqing Ding#, Yan Zhao, Zhangding Wang, Junjie Chen, Zerun Jiang, Yan Zhang, Guifang Xu, Jingjing Zhang, Jianwei Zhou, Beicheng Sun*, Xiaoping Zou*, Shouyu Wang*. METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. Gut. 2020 Jul;69(7):1193-1205.
(8) Qiang Wang#, Wei Geng#, Huimin Guo#, Zhangding Wang, Kaiyue Xu, Chen Chen, Shouyu Wang*. Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer. Journal of Hematology&Oncology. 2020 May;13(1):57.
(9) Zhangding Wang#, Qiang Wang#, Guifang Xu#, Na Meng#, Xinli Huang, Zerun Jiang, Chen Chen, Yan Zhang, Junjie Chen, Aiping Li, Nan Li, Xiaoping Zou, Jianwei Zhou, Qingqing Ding*, Shouyu Wang*. The long noncoding RNA CRAL reverses cisplatin resistance via the miR-505/CYLD/AKT axis in human gastric cancer cells. RNA Biology. 2020 Nov;17(11):1576-1589.
(10) Qingsong Hu#, Chunlai Li#, Shouyu Wang#, Yajuan Li#, Bo Wen, Yanyan Zhang, Ke Liang, Jun Yao, Youqiong Ye, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, David H. Hawke, Jeffrey R. Marks, Leng Han, Mien-Chie Hung, Bing Zhang, Chunru Lin*, Liuqing Yang*, LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Research. 2019 Apr;29 (4):286-304.
(11) Jie Wu#, Zerun Jiang#, Chen Chen#, Qingsong Hu, Ziyi Fu, Junjie Chen, Zhangding Wang, Qiang Wang, Aiping Li, Jeffrey R. Marks, Changying Guo, Yun Chen, Jianwei Zhou, Liuqing Yang, Chunru Lin, Shouyu Wang*, CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis. Cancer Letters. 2018 Aug; 430:179-192.
(12) Shouyu Wang#, Ke Liang#, Qingsong Hu#, Jian Song, Yuedong Yang, Jun Yao, Selanere Mangala, Chunlai Li, Wenhao Yang, Peter K. Park, David H. Hawke, Jianwei Zhou, Yan Zhou, Weiya Xia, Mien-Chie Hung, Jeffery R. Marks, Gary E. Gallick, Gabriel Lopez-Berestein, Elsa R. Flores, Anil K. Sood, Suyun Huang, Dihua Yu, Liuqing Yang*, Chunru Lin*, A JAK2-binding Long Noncoding RNA Promotes Breast Cancer Brain Metastasis. Journal of Clinical Investigation. 2017 Dec;127(12):4498-4515.
(13) Chunlai Li#, Shouyu Wang#, Zhen Xing, Aifu Lin, Ke Liang, Jian Song, Qingsong Hu, Jun Yao, Zhongyuan Chen, Peter K. Park, David H. Hawke, Jianwei Zhou, Yan Zhou, Shuxing Zhang, Han Liang, Mien-Chie Hung, Gary E. Gallick, Leng Han, Chunru Lin* and Liuqing Yang*, A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis, Nature Cell Biology. 2017 Feb;19(2):106-119.
(14) Shouyu Wang, Xuming Wu, Jianbing Zhang, Yansu Chen, Jin Xu, Xiaowei Xia, Song He, Fulin Qiang, Aiping Li, Yongqian Shu, Oluf Dimitri Røe, Gang Li, Jianwei Zhou*, CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer. Gut. 2013 Apr;62(4):496-508.
(15) Shouyu Wang, Xuming Wu, Yansu Chen, Jianbing Zhang, Jingjing Ding, Yan Zhou, Song He, Yongfei Tan, Fulin Qiang, Jin Bai, Jinyan Zeng, Zhenghua Gong, Aiping Li, Gang Li, Oluf Dimitri Røe, and Jianwei Zhou*, Prognostic and Predictive Role of JWA and XRCC1 Expressions in Gastric Cancer. Clinical Cancer Research. 2012 May;18(10):2987-96.
(16) Shouyu Wang, Zhenghua Gong, Rui Chen, Yunru Liu, Aiping Li, Gang Li and Jianwei Zhou*, JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks. Nucleic Acids Research. 2009 Apr;37(6):1936-50.
