个人简介：
孙倍成教授现任安徽医科大学第一附属医院党委副书记、院长，教育部肿瘤免疫医药基础研究创新中心主任，肿瘤免疫微环境研究及治疗安徽省重点实验室主任。教育部长江学者特聘教授，国家自然科学基金杰出青年基金获得者，国家万人计划领军人才，享受国务院政府特殊津贴。安徽省医学会副会长，《安徽医科大学学报》副主编，Journal of Hepatology杂志编委。
孙倍成教授目前获排名第一的省部级一等奖4项，以第一作者或通讯作者发表SCI文章100余篇，包括Nature Reviews Clinical Oncology、Nature、Cell、Immunity、Cancer Cell、Nature Cancer、Journal of Hepatology、Hepatology，Advanced Materials等，总影响因子1000余分，论文引用10000余次。主持“精准医学研究”国家重点研发计划，国家杰出青年科学基金、国家自然科学基金重点项目、重点国合项目等多项国家级和省部级课题。
研究方向：
慢性炎症和肿瘤。
肿瘤微环境、免疫治疗与肝癌。
肝脏移植及腹腔器官移植的临床基础研究。
代表性论文：
1、Lao Y, Cui X, Xu Z, Yan H, Zhang Z, Zhang Z, Geng L, Li B, Lu Y, Guan Q, Pu X, Zhao S, Zhu J, Qin X, Sun B. Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma. J Hepatol. 2024 Nov;81(5):847-861. doi: 10.1016/j.jhep.2024.05.034. Epub 2024 May 31.
2、Yijun Lu; Qikai Sun; Qifei Guan; Zechuan Zhang; Qifeng He; Jianbo He; Zetao Ji; Wenfang Tian; Xiaoliang Xu; Yang Liu; Yin Yin; Chang Zheng; Senlin Lian; Bing Xu; Pin Wang; Runqiu Jiang;Beicheng Sun ; The XOR-IDH3α axis controls macrophage polarization in hepatocellular carcinoma,Journal of Hepatology, 2023, 79(5): 1172-1184
3、Jin K, Shi Y, Zhang H, Zhangyuan G, Wang F, Li S, Chen C, Zhang J, Wang H, Zhang W, Sun B. A TNFα/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis. J Hepatol. 2023 Aug;79(2):403-416. doi: 10.1016/j.jhep.2023.03.039. Epub 2023 Apr 9.
4、Hua Su; Fei Yang; Rao Fu; Brittney Trinh; Nina Sun; Junlai Liu; Avi Kumar; JacopoBaglieri; Jeremy Siruno; Michelle Le; Yuhan Li; Stephen Dozier; Ajay Nair; Aveline Filliol;Nachanok Sinchai; Sara Brin Rosenthal; Jennifer Santini; Christian M. Metallo; Anthony Molina;Robert F. Schwabe; Andrew M. Lowy; David Brenner; Beicheng Sun; Michael Karin ; Collagenolysisdependent DDR1 signalling dictates pancreatic cancer outcome, Nature, 2022, 61(7931): 366-372
5、Xia Anliang; Yuan Wenwen; Wang Qiang; Xu Jianbo; Gu Yayun; Zhang Liansheng; Chen Chen;Wang Zhangding; Wu Di; He Qifeng; Yu Weiwei; Wang Fei; Xue Cailin; Zhang Yan; Bao Guojian; Tao Xuewen; Liu Siyuan; Wang Shouyu; Hu Zhibin; Sun Beicheng ; The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription,Nature Cancer, 2022, 3(2): 203-218
6、Zhang, Wenjie; Zhangyuan, Guangyan; Wang, Fei; Jin, Kangpeng; Shen, Haiyuan; Zhang,Liansheng; Yuan, Xiang; Wang, Jincheng; Zhang, Haitian; Yu, Weiwei; Huang, Ruyi; Xu, Xiaoliang;Yin, Yin; Zhong, Guisheng; Lin, Anning; Sun, Beicheng ; The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation,Immunity, 2021, 54(6): 1168-1185
7、 Hua Su; Fei Yang; Rao Fu; Xin Li; Randall French; Evangeline Mose; Xiaohong Pu; Brittney Trinh; Avi Kumar; Junlai Liu; Laura Antonucci; Jelena Todoric; Yuan Liu; Yinling Hu; Maria T;Diaz-Meco; Jorge Moscat; Christian M. Metallo; Andrew M. Lowy; Beicheng Sun; Michael Karin ;
Cancer cells escape autophagy inhibition via NRF2- induced macropinocytosis, Cancer Cell, 2021,39(5): 678-693
8、Huang Q, Wu X, Wang Z, Chen X, Wang L, Lu Y, Xiong D, Liu Q, Tian Y, Lin H, Guo J, Wen S, Dong W, Yang X, Yuan Y, Yue Z, Lei S, Wu Q, Ran L, Xie L, Wang Y, Gao L, Tian Q, Zhou X, Sun B, Xu L, Tang Z, Ye L. The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes. Cell. 2022 Oct 27;185(22):4049-4066.e25. doi: 10.1016/j.cell.2022.09.020. Epub 2022 Oct 7.
9、Wang X, He Q, Shen H, Xia A, Tian W, Yu W, Sun B. TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma. J Hepatol. 2019 Oct;71(4):731-741. doi: 10.1016/j.jhep.2019.05.015. Epub 2019 Jun 5.
10、Hou J, Karin M, Sun B. Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age? Nat Rev Clin Oncol. 2021 May;18(5):261-279. doi: 10.1038/s41571-020-00459-9. Epub 2021 Jan 19.
